Topical Mitomycin C and Radiation Induce Conjunctival DNA-Polyploidy
نویسندگان
چکیده
منابع مشابه
Topical Mitomycin C and Radiation Induce Conjunctival DNA-Polyploidy
INTRODUCTION Atypical cell changes often occur following treatment of premalignant or malignant conjunctival neoplasias with topical mitomycin C (MMC) and/or radiation. These reactive, non-neoplastic alterations of the conjunctival epithelium can be a differential diagnostic problem. Our aim was to investigate changes in the nuclear DNA-distribution of conjunctival epithelial cells after MMC- a...
متن کاملTopical mitomycin C chemotherapy for conjunctival melanoma and PAM with atypia.
AIM To evaluate topical mitomycin C (MMC) chemotherapy in the treatment of conjunctival melanoma and primary acquired melanosis with atypia. METHODS In a phase I clinical trial, 10 patients with conjunctival melanoma and/or primary acquired melanosis with atypia were treated with topical MMC 0.04% four times daily. Four patients were given MMC for 28 days as a primary treatment. Six patients ...
متن کاملAmniotic membrane graft for primary pterygium: comparison with conjunctival autograft and topical mitomycin C treatment.
AIM To study the efficacy and safety of amniotic membrane graft as an adjunctive therapy after removal of primary pterygium, and to compare the clinical outcome with conjunctival autograft and topical mitomycin C. METHODS 80 eyes of 71 patients with primary pterygia were treated with excision followed by amniotic membrane graft. The result was compared retrospectively with 56 eyes of 50 patie...
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Despite various developments in many fields of ophthalmology, the surgical therapy of open-angle glaucoma has remained mostly unchanged over the last 30 years. Ever since the introduction of intraoperative mitomycin and postoperative subconjunctival injections of 5-fluorouracil (5-FU), trabeculectomy has not markedly been altered. These facts stand in contrast to the need for a more efficient s...
متن کاملAirway complications from topical mitomycin C.
OBJECTIVE Topical application of mitomycin C appears to be a useful adjunct in reducing cicatricial scarring of the airways. Human and animal studies have demonstrated the efficacy and safety of mitomycin C topically in the treatment of airway stenosis at concentrations ranging from 0.4 mg/mL to 10 mg/mL. Although no reports of mitomycin C toxicity have been reported in the otolaryngology liter...
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ژورنال
عنوان ژورنال: Analytical Cellular Pathology
سال: 2001
ISSN: 0921-8912,1878-3651
DOI: 10.1155/2001/961735